There are two major questions with subparts on this examination (your debate performance and submission counts for the remaining one-third of your grade). Please answer each of these two questions in the Blue Book that you have been provided. Please write on alternate lines only and clearly indicate your final answer to problems. Attach your debate portfolio to the blue book when you submit your examination. Each question is equally weighted toward your total grade on this exam.

1) Pedigree Analysis - This section has two parts; you must answer both.

a) Construct a pedigree based upon the following information:

i) The proband (affected individual that led to the construction of the pedigree) exhibits the trait

ii) Neither her husband nor her only sibling, an older brother, exhibit the trait

iii) The proband has five children by her current husband: the oldest is a boy, followed by a girl, then another boy, and then identical twin girls. Only the second oldest fails to exhibit the trait

iv) The parents of the proband both show the trait

(1) Determine the mode of inheritance (autosomal dominant or autosomal recessive) for this trait; explain your reasoning

(2) Can you deduce the genotype of the proband's husband? If so, what is it? If not, why not?

b) Deduce the mode of inheritance for the pedigree that follows.

i) Identify the genotype of each of the following individuals

(1) II-2

(2) II-3

(3) III-3

2) Extensions to Mendelism - This section has two parts. You must answer both.

a) A woman with type A blood, whose father had type O blood and mother type AB, marries a man with type AB blood whose mother had type A and father type B. {Hint: the allelic relationships are (I^A = I^B) > i}

i) Draw the pedigree for this family

ii) Assign genotypes to the woman and man

iii) What is the probability that their first child will have blood type AB?

b) Chrissy is a 17 year-old who is very upset when her hair begins to fall out in big patches. Her sister Mandy, fearing that she will also lose her hair, asks their mother Pam if the condition is inherited. Pam confesses that she has worn a wig for years because she, too, has suffered serious hair loss. The girls' maternal grandmother Liz and their father Joe are bald. The girls' maternal grandfather Adam, and paternal grandparents Charles and Polly, each has a full head of hair. The condition in this family is known as alopecia areata and it is inherited as an autosomal dominant trait.

i) Draw a pedigree for this family. Please label each individual with his or her name.

ii) The sisters blame their hair loss on their bald father because their mother has some hair. From which parent did they inherit alopecia? What is the evidence for your conclusion?

iii) What would be the chance of Chrissy's first child having alopecia?

iv) Name a phenocopy of alopecia.